Welcome to Rotundine resources

Rotundine.com contains information about Tetrahydropalmatine and L-Tetrahydropalmatine. Common name for this drug is Rotundine.

You will find combined list of research, publications and news on clinical trials.

The following might interest reader:

  • Rotundine
  • Rotundin
  • Hyndarine
  • Tetrahydropalmatine
  • L-Tetrahydropalmatine
  • Corydalis Rhizoma


  • February 2021, Maunufacturers and resellers updated

  • 2020 Corona suspends new clinical trials


By 天問 - 玉咲葛藤, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=5002523

Corydalis (Yan Hu Suo)and Stephania rotunda.

Stephania rotunda is traditionally used for the treatment of a wide range of ailments throughout Southeast Asia (Cambodia, Vietnam, Laos, and India). The roots primarily contain l-tetrahydropalmatine.

For centuries, Corydalis Rhizoma has been used in Korean traditional medicine.


Tetrahydropalmatine (THP) is an isoquinoline alkaloid found in several different plants such as Corydalis and Stephania Rotunda. Common drug name for this is Rotundine and Hyndarine. Tetrahydropalmatine is an alkaloid compound and a prominent anti-inflammatory agent found in plants.

Medical use

Rotundine has significant effect of analgesia. Rotundine is used for producing tranquilliser with safe sleeping effect and without side-effects. Tetrahydropalmatine has been demonstrated to possess analgesic effects and may be beneficial in the treatment of heart disease and liver damage.It is a blocker of voltage-activated L-type calcium channel active potassium channels. It is a potent muscle relaxant. It has also shown potential in the treatment of drug addiction to both cocaine and opiates, and preliminary human studies have shown promising results.

Because of its low toxicity and less adverse reactions, Rotundine has attracted a lot of attention in pain management. It has great market prospects and deserves further development and utilization.